Objective: There has been considerable debate over the value of assessing the gastric residual volume (GRV), or the quantity of food still in the stomach, for patients with ventilator-associated pneumonia (VAP). A study on critically sick patients receiving mechanical ventilation was done to find out whether GRV has any effect on the incidence of VAP. Methods: The critical care unit at Mayo Hospital received 150 adult patients from December 2021 to March 2023. This descriptive research was conducted on these patients. Gastric intolerance was determined by GRV readings greater than 250 ml, which were taken every three hours. The mortality rate, GRV, VAP, stay on mechanical ventilation, stay in the intensive care unit, SOFA and APACHE II scores, and frequency of vomiting were also noted. Results: According to the quantity of gastric residual volume (GRV) that the patients produced—one group generating more than 250ml and the other producing less than or equal to 250ml—patients were split into two groups for the research. Longer hospitalizations in the intensive care unit (ICU), more frequent use of mechanical ventilation, and higher ratings for disease severity (as determined by APACHE II and SOFA scores) were also characteristics of the group with a greater GRV. In addition, compared to the lower GRV group, more patients in the higher GRV group reported experiencing illness and vomiting. Patients with higher APACHE II and SOFA scores were more likely to have a GRV larger than 250 ml. Additionally, it was shown that the rise in GRV was greater in individuals who did not survive compared to those who did. Conclusions: Elevated GRV wasn’t related to a higher incidence of VAP, duration of stay in the ICU, or death. As a result, it is not advised for critically sick patients to routinely assess GRV, a crucial component of the VAP preventive bundle.