Background: Cardiovascular diseases (CVDs) constitute a major global health burden, and understanding the multifaceted contributors to their risk and progression is crucial for effective prevention and management. Genetic factors play very pivotal part in shaping an individual’s susceptibility to CVDs, influencing not only the likelihood of disease onset but also its trajectory. This study delves into the intricate interplay between genetic factors and cardiovascular disease, aiming to uncover key insights that can inform personalized healthcare strategies. Aim: The main goal of our current research is to explore specific genetic determinants that contribute to risk and progression of cardiovascular diseases. By identifying and understanding these factors, we aim to offer the more nuanced understanding of genetic landscape associated with CVDs, ultimately paving the way for targeted interventions and precision medicine approaches. Methods: A comprehensive review of existing literature on cardiovascular genetics, coupled with cutting-edge genetic analyses, forms the foundation of our methodology. We leverage large-scale genetic datasets, employing advanced techniques such as genome-wide association studies (GWAS) and polygenic risk score calculations to discern the genetic underpinnings of cardiovascular disease susceptibility and progression. Additionally, we integrate clinical data to contextualize genetic findings and provide a holistic understanding of the complex interplay between genes and cardiovascular health. Results: Our findings reveal a spectrum of genetic factors significantly associated with cardiovascular disease risk and progression. Through meticulous analysis, we identify specific genetic markers, pathways, and variations that contribute to individualized susceptibility. Furthermore, we delineate the influence of genetic factors on diverse cardiovascular phenotypes, shedding light on potential therapeutic targets and novel avenues for preventive interventions. Conclusion: Our current research underscores very significant part of genetic factors in shaping the landscape of cardiovascular diseases. The identified genetic markers and pathways not only enhance our understanding of disease mechanisms but also hold promise for the development of targeted therapeutic interventions. Recognizing the diversity in genetic susceptibility among individuals allows for the formulation of more precise and effective strategies for CVD prevention and treatment, moving us closer to the era of personalized cardiovascular medicine.
Keywords: Cardiovascular disease, Genetic factors, Genome-wide association studies, Polygenic risk score, Precision medicine, Disease susceptibility, Cardiovascular genetics, Therapeutic interventions, Personalized healthcare, Risk assessment.