Background: Pre-diabetes mellitus has emerged as a significant health concern, with its association with cardiovascular diseases garnering increasing attention. This study delves into the complex interplay between pre-diabetes mellitus and the risk of heart failure, aiming to provide a thorough understanding of the epidemiological and clinical dynamics. Aim: The primary aim of this research is to investigate the relationship between pre-diabetes mellitus and the risk of developing heart failure, with a specific focus on mortality outcomes. By conducting a comprehensive analysis, we seek to identify key factors and potential markers that contribute to the progression from pre-diabetes to heart failure and assess their impact on overall mortality rates. Methods: This study employs a multi-faceted methodology, combining rigorous epidemiological analyses with detailed clinical examinations. A large-scale retrospective cohort study will be conducted, utilizing electronic health records to identify individuals with pre-diabetes mellitus and tracking their outcomes over an extended period. Clinical assessments will include comprehensive metabolic profiling, cardiac imaging, and biomarker analyses to elucidate the underlying mechanisms linking pre-diabetes to heart failure. Results: The findings of this study aim to unravel the intricate relationship between pre-diabetes mellitus and heart failure, shedding light on the prevalence of heart failure in individuals with pre-diabetes and the associated mortality risk. Statistical analyses will be employed to discern patterns, risk factors, and potential predictive markers, providing a nuanced understanding of the progression from pre-diabetes to heart failure. Conclusion: This comprehensive epidemiological and clinical analysis seeks to contribute valuable insights into the nexus of pre-diabetes mellitus, heart failure, and mortality. The outcomes of this study will not only enhance our understanding of the intricate connections between these health conditions but also have implications for preventive strategies, early interventions, and patient care.
Keywords: Pre-diabetes mellitus, heart failure, mortality, epidemiology, clinical analysis, risk factors, cardiovascular diseases, metabolic profiling, biomarkers, preventive strategies.