Background: Amyloidosis, a category of illnesses distinguished by aberrant protein deposition, frequently appears with a variety of medical symptoms. Because oral tissues are easily accessible and have high diagnostic potential, they have emerged as a possible path for amyloidosis detection. The purpose of the research is to investigate the diagnostic utility of oral tissue biopsy in unravelling amyloidosis, with a focus on oral symptoms, and to assess the usability of this diagnostic method. Aim: The major goal of this study is to determine the diagnostic accuracy of oral tissue biopsy for amyloidosis. This study intends to improve our understanding of how amyloidosis presents in the oral cavity by looking into the many oral symptoms associated with the illness. Furthermore, the study aims to determine the practicability and dependability of oral tissue biopsy as a diagnostic tool for amyloidosis. Methods: A detailed clinical research will be carried out on a group of individuals with suspected or confirmed amyloidosis. Oral tissue specimens will be taken and analyzed histopathological and immunohistochemically to detect amyloid deposits. Symptoms that are clinical in the oral cavity will be well recorded. The study will use statistical analysis to assess the sensitivity, specificity, and overall diagnostic reliability of oral tissue biopsy in the setting of amyloidosis. Results: The findings will give information on the prevalence and patterns of amyloidosis-related oral symptoms. Furthermore, the diagnostic performance of an oral tissue biopsy, particularly its specificity and sensitivity, will be investigated. The relationship between oral findings and systemic disease development will be investigated, adding important information to our knowledge of amyloidosis. Conclusion: The research presented here emphasises the importance of oral tissue biopsy as a diagnostic tool for amyloidosis, providing information on its efficacy and accuracy in identifying the illness. The observed oral signs may serve as important markers for early diagnosis and treatment. The discoveries will help to further our understanding of amyloidosis and open the path for more effective diagnostic techniques, perhaps enhancing patient outcomes.
Keywords: Amyloidosis, Oral Manifestations, Diagnostic Value, Tissue Biopsy, Histopathology, Immunohistochemistry, Sensitivity, Specificity, Clinical Study.