Background: The distinction between ameloblastic carcinoma (AC) and ameloblastoma is crucial for accurate diagnosis and treatment planning. DNA content and clinicopathological features have been recognized as potential indicators to differentiate these two odontogenic neoplasms. Aim: This study aimed to investigate the utility of DNA content and clinicopathological features in distinguishing ameloblastic carcinoma from ameloblastoma, providing valuable insights for improved diagnostic accuracy and patient management. Methods: Archival samples of confirmed cases of ameloblastic carcinoma and ameloblastoma were retrospectively analyzed. DNA content was assessed through advanced techniques, and clinicopathological features were meticulously examined. Statistical analyses were employed to identify significant differences between the two groups. Results: The DNA content analysis revealed distinct patterns between ameloblastic carcinoma and ameloblastoma cases. Additionally, clinicopathological features such as cellular atypia, mitotic activity, and invasion were significantly more pronounced in ameloblastic carcinoma. These findings collectively contribute to a reliable differentiation between the two entities. Conclusion: The integration of DNA content analysis and clinicopathological features proves to be a robust approach in distinguishing ameloblastic carcinoma from ameloblastoma. This comprehensive diagnostic strategy enhances accuracy and facilitates timely and appropriate clinical interventions, thereby improving patient outcomes.
Keywords: Ameloblastic carcinoma, ameloblastoma, DNA content, clinicopathological features, diagnostic accuracy, differentiation, odontogenic neoplasms.