Introduction: Acute appendicitis is the most common indication for urgent intra- abdominal surgery [1]. The conventional pathophysiologic model of acute appendicitis is based on a relationship between time and disease progression; risk of perforation increases as time elapses from onset of disease to treatment. Observational research has demonstrated an association between time to treatment and perforation [2]; indirect evidence for this association has also come from studies linking impaired health care access to increased risk of perforation [3]. Objective: Determine the frequency of perforation in patients undergoing appendectomy for acute appendicitis at Sandeman Provincial Hospital, Quetta. Study Design: Descriptive Cross-Sectional Study. Setting: This study was conducted at Department of General Surgery, Sandeman Provincial Hospital, Quetta, Pakistan. Duration: Six months after the approval of synopsis from December 20, 2020 to June 19, 2021. Materials and Methods: patients who fulfilled the inclusion criteria and visited to Sandeman Provincial Hospital, Quetta were included in the study. Informed consent was taken after explaining the procedure, risks and benefits of the study. Alvarado score of all patients was determined. Patients were diagnosed as cases of acute appendicitis. An ultrasound abdomen was requested in all patients to confirm the diagnosis of acute appendicitis. All patients then underwent open appendicectomy under general anesthesia. All the collected data were entered into the proforma attached at the end and used electronically for research purpose. Results: Mean ± SD of age was 31.6±4.9 years. In distribution of gender, 120 (67.8%) were male while 57 (32.2%) were female. Mean ± SD of Alvarado score was 7.6±2.2 with C.I (7.27…….7.92). Perforation was found to be in 44 (24.9%) patients. Conclusion: Ir is to be concluded that perforation is a frequent finding in patients undergoing appendectomy for acute appendicitis. Furthermore, our findings outline the need for future research to investigate those factors that could be considered as higher risk of perforation.
Keywords: Alvarado Score, Appendicectomy, Acute Appendicitis, Perforation, Specificity.