Effects of Amlodipine on Bone Metabolism in Orchidectomised Spontaneously Hypertensive Rats

Subject Area: Pharmacology
Helena Zivna; Iveta Gradošová; Pavel Zivny; Eva Cermakova; Vladimir Palicka
Pharmacology (2018) 102 (1-2): 67–73.

Spontaneously hypertensive rats (SHR) represent a model of essential hypertension. We studied the effect of amlodipine (AML) on bone markers, bone mineral density (BMD), and biomechanical properties of osteopenic bone induced by orchidectomy in male SHR. Rats were allocated to 3 groups and were sacrificed after 12 weeks: sham-operated control; orchidectomised control; and orchidectomised receiving a diet supplemented with AML. Indicators of bone turnover were assessed in bone homogenate, BMD was measured by dual energy X-ray absorptiometry, and the femurs were subjected to biomechanical testing. Long-term AML administration does not have a negative impact on bone metabolism and density in male SHR.

Keywords: Spontaneously hypertensive rat, Amlodipine, Bone metabolism, Orchidectomy
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