Effective Desensitization to Tocilizumab in Delayed Hypersensitivity Reaction

Subject Area: Pharmacology
Gabriele Cortellini; Fabio Mascella; Margherita Simoncelli; Domenico Lippolis; Maria Cristina Focherini; Fabio Cortellini; Chiara Cherubini; Barbara Gavioli; Giorgio Ballardini
Pharmacology (2018) 102 (1-2): 114–116.

We present tocilizumab desensitization of a 47-year-old woman affected by rheumatoid arthritis with full body delayed erythematous urticarial reaction. Skin test for tocilizumab gave cutaneous reaction after 6 h at 20 mg/mL. The schedule of desensitization was then adapted for non-immediate reaction. We prepared a desensitization procedure reaching the cumulative dose of 516 mg in 5 weeks. After 6 months, the repetition of skin tests had a negative result, with demonstration of tolerance induction. Today the patient has good control of the disease.

Keywords: Tocilizumab, Desensitization, Delayed hypersensitivity
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